Which section determines the level of a physiological or physical function over a period of time?
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Which section determines the level of a physiological or phy…
Which section determines the level of a physiological or physical function at a point in time
Which of the following community health workers working for…
Which of the following community health workers working for BRAC are responsible for checkup during pregnancy i.e. antenatal checkup ?
Which of the following foods is NOT a good source of vitamin…
Which of the following foods is NOT a good source of vitamin E?
An adult may need more than the 75 milligram or 90 milligram…
An adult may need more than the 75 milligram or 90 milligram vitamin C RDA if she/he has severe skin burns, is battling an infection, or smokes cigarettes.
The clinical department where x-rays and CT-scans are proces…
The clinical department where x-rays and CT-scans are processed is:
Which agency can deny or revoke the RCPs license for legal o…
Which agency can deny or revoke the RCPs license for legal or ethical infractions?
Where does breathing begin?
Where does breathing begin?
Which is NOT true about Typhoid Fever globally?
Which is NOT true about Typhoid Fever globally?
Lysozyme is a well-known antimicrobial enzyme that hydrolyze…
Lysozyme is a well-known antimicrobial enzyme that hydrolyzes the β-(1,4) glycosidic bonds between N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) in bacterial cell walls, leading to cell lysis. Its catalytic mechanism has been debated extensively, with two main proposals resembling SN1 and SN2 pathways. In the SN1-like mechanism—originally proposed by Phillips—the enzyme binds and distorts the substrate, facilitating the formation of an oxocarbenium ion intermediate that is subsequently attacked by water, leading to bond cleavage in a stepwise manner. In contrast, the SN2-like mechanism envisions a concerted process where bond cleavage and bond formation occur simultaneously, potentially involving a covalent glycosyl-enzyme intermediate that is later hydrolyzed to release the product. Recent kinetic isotope studies and QM/MM simulations suggest that lysozyme may employ features of both mechanisms, with the reaction pathway being influenced by substrate structure and reaction conditions. The following intermediate is formed by which mechanism?