1) What set of genes was up-regulated after traumatic brain injury in many DGRP lines, regardless of age and diet? (Answer in one sentence or less) 2) What experiment did Dr. Wassarman do that suggests the up-regulation of these genes isn’t just correlated with traumatic brain injury, but actually contributes to early mortality after traumatic brain injury in a causal way, at least in some genetic backgrounds. (Answer in six sentence or less.)
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Adolescent rats and humans that experience intermittent alco…
Adolescent rats and humans that experience intermittent alcohol exposure are at greater risk of developing anxiety later in life. Scientists injected viruses carrying CRISPR components into the amygdalas of mice that had NOT experienced intermittent ethanol exposure during adolescence in order to edit the mice genomes in a way that mimicked intermittent ethanol exposure. A. What CRISPR components were the virus carrying? [dcas9KRAB]. B. How did this injection affect the Arc enhancer region? [methylation] C. How did this injection affect Arc expression? [decreased] D. How did this injection affect mice behavior? [increased]
Dr. Wassarman also has data showing that TBI stimulates the…
Dr. Wassarman also has data showing that TBI stimulates the formation of lipid droplets that are associated with mitochondria. Dr. Wassarman’s current hypothesis is that lipid droplet formation and trafficking to mitochondria protects neurons (at least partially) against traumatic brain injury. Which genotype would you expect to have the fewest lipid droplets near mitochondria after traumatic brain injury: A. Lis-1mutant/Lis-1wild-type B. Lis-1mutant/Lis-1mutant C. Lis-1wild-type/Lis-1wild-type
The arrow is pointing to insoluble protein aggregation seen…
The arrow is pointing to insoluble protein aggregation seen in both Alzheimer’s disease brains and and brains from people with chronic traumatic encephalopathy. What protein is aggregating in neurons in both of these diseases?
Dr. Wassarman conducted experiments to examine DNA content i…
Dr. Wassarman conducted experiments to examine DNA content in his fly model of Ataxia Telangiectasia. Consider his Fluorescence Activated Cell Sorting (FACS) data below. First, just compare Panels A and B. In this comparison, Panel B indicates that when Ataxia Telangiectasia Mutated (ATM) is not present at wild-type (control) levels [replicate]. Next consider all the panels, and then compare Panels B and D. The best conclusion that can be drawn from this comparison is that when ATM is not present at wild-type levels [apoptosis].
Who is more likely to express the trait that is depicted in…
Who is more likely to express the trait that is depicted in this pedigree?
The loss one copy of an autosome is called
The loss one copy of an autosome is called
Using genetic mapping and the crossover frequencies provided…
Using genetic mapping and the crossover frequencies provided, determine the order of these genes.
Which of the following is a core function of Electronic Heal…
Which of the following is a core function of Electronic Health Records (EHRs) according to the text?
What is the ratio of the actual water vapor content to its s…
What is the ratio of the actual water vapor content to its saturated capacity at a given temperature?