Mark, a 30-year-old man, is admitted to the hospital with a…

Mark, a 30-year-old man, is admitted to the hospital with a fever and sore throat. On examination, he has an elevated body temperature and an enlarged spleen. Laboratory tests show a reduced total white blood cell count. Based on the provided clinical scenario and examination findings, which pathological condition is likely affecting Mark, characterized by a decreased white blood cell count, leading to an increased susceptibility to infections and an enlarged spleen?

Maria, a 60-year-old woman, has been experiencing persistent…

Maria, a 60-year-old woman, has been experiencing persistent pain and stiffness in her knees for the past few years. She has a sedentary lifestyle and is overweight. She seeks physical therapy for her knee problems, and the therapist suspects osteoarthritis. During the evaluation, the therapist reviews her medical history and lifestyle factors to identify potential risk factors contributing to the development of osteoarthritis. Based on Maria’s case, which of the following primary risk factors is MOST LIKELY contributing to the development of osteoarthritis in her weight-bearing joints?