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Fill in the blanks with the best answer from the dropdown menu. Use each item from the dropdown menu only once.     In the immune system, the complement cascade tags [pathogens] for [phagocytosis] by [immunecells]. In the brain, the complement system tags [synapses] for [pruning] by [microglia].

(0.75 point) What is one piece of evidence that has led to or supports the Amyloid Cascade Hypothesis? Limit your answer to four sentences or less. (0.75 point) What is one scientific finding that suggests this hypothesis might have some shortcomings? Limit your answer to three sentences or less.

Nusinersen is an FDA-approved antisense oligonucleotide drug to treat spinal muscular atrophy. Nusinersen binds to SMN2 mRNA

In 2018, a genome-wide association study for major depressive disorder (MDD) was published in the journal Nature Communications. The first Manhattan plot below is from that publication. In this study, genome-wide significant SNPs had a P  7.3, and the cutoff for suggestive SNPs was P=10−6 [-Log10(6)].   1) How many independent loci are associated with MDD at a genome-wide significance level in the 2018 GWAS? [2] 2) If the only difference between these two studies is sample size, which GWAS has the biggest sample size? [2019] 3) If the only difference between these two studies is sample size, do the genome-wide significant variants identified in the 2018 study have a bigger or smaller effect size than most of the genome-wide significant variants identified in the 2019 study? [bigger]

Which characteristic distinguishes Huntington’s Disease from other diseases?

The AV Node is the heart’s original ‘pacemaker”.

Normal Reabsorption of fluid into the capillary takes place at the arterial end or venous end of the capillary?

The pacemaker action potential is identical to the cardiac contractile cell action potential.

The pulmonary trunk receives blood from the:

The closing of the semilunar valves: