Celiac disease is an immune disorder that is triggered by an…

Celiac disease is an immune disorder that is triggered by an environmental agent (gluten) in genetically predisposed individuals. The genetic basis of the disease is shown by the frequent intra-familial occurrence. Select all correct answer/s.  1. There is close association with the human leukocyte antigen (HLA) DR-DQ2 and/or DR4-DQ8 gene locus 2. More than 99% of individuals with celiac disease have HLA DR3-DQ2 and/or DR4-DQ8 3. Homozygotes for DR3-DQ2 are at the highest risk for celiac disease 4. While the presence of either the HLA-DQ2 or DQ8 genotype is essential to confer disease, it is not sufficient, and environmental factors and other genes at non-HLA loci must also participate