The nurse is conducting a well-child assessment for a 5-year…

The nurse is conducting a well-child assessment for a 5-year-old boy in preparation for kindergarten. The boy’s grandmother is his primary caregiver because the boy’s mother has suffered from depression and substance abuse issues. The nurse understands that the child is at increased risk for which developmental problem?

Drug A is an anticlotting agent that is chiefly metabolized…

Drug A is an anticlotting agent that is chiefly metabolized by CYP1A2. It was found that patients who smoke >10 cigarettes per day received increased benefit of the drug at a given dose, relative to nonsmokers. This is despite a significantly lower serum concentration of the drug in smokers. Which of the following could best explain these observations?