A newborn baby is born at 35 weeks gestation to an unbooked…

A newborn baby is born at 35 weeks gestation to an unbooked mother. The neonate presents in respiratory distress with nasal discharge, peeling rash on the palms of the hands and soles of the feet and hepato-splenomegaly. What is the most likely congenital infection in this child?

A 2 year old boy, recently diagnosed with HIV presents with…

A 2 year old boy, recently diagnosed with HIV presents with cough, fever and cervical lymphadenopathy weeks after starting antiretroviral therapy. The chest x-ray shows new pulmonary infiltrates and repeat bloods show an improved CD 4 count. What is the most likely reason for this clinical presentation?

A 9 year old boy presents with a unilateral headache which o…

A 9 year old boy presents with a unilateral headache which occurs twice a week for the past 6 months. It is not associated with visual or auditory symptoms. The headache lasts about 2 hours and sometimes it is associated with nausea and vomiting. It is relieved by sleep or by painkillers. His systemic examination is normal. What is the most likely diagnosis?

A 6 year old boy presents with an acute loss of ability to s…

A 6 year old boy presents with an acute loss of ability to stand. This was preceded by a dramatic onset of headache. On examination he has short stature, microcephaly and bifid right thumb. He is alert and has a power of 2/5 on his right upper limb, 5/5 on the left upper limb, 3/5 on the right lower limb and 5/5 on his left lower limb.  What is the most likely cause of his limb weaknesses?