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塔米宁教授认为，睡眠对学习的最大作用是什么？

游戏公司为什么大力推广微交易？

Dr. Wassarman discovered a genetic suppressor of A-T in his dominant modifier screen. What is the genotype of the suppressor? Choose the letter that corresponds to the correct genotype below.  A. stringmutant / stringwild-type (non-mutant) B. stringmutant / stringmutant C. stringwild-type (non-mutant) / stringwild-type (non-mutant) D. P35mutant / P35wild-type (non-mutant) E. P35mutant / P35mutant   Be careful when you mark your selection because the order of the letters might be mixed-up!

In Fragile X Syndrome there is [increased] protein synthesis downstream of mGluR activation. One mRNA whose translation is normally regulated by FMRP is [arc]. In Fragile X Syndrome the aberrant translation of this mRNA leads to an excess of [internalization] and [depression].  

Select True or False for each statement below. The microsatellite expansion in TDP-43 might disrupt its nucleocytoplasmic transport causing it to build-up in the cytoplasm. [false1] Mutations in the prion-like domain of C9orf72 that cause familial ALS increase its propensity to form insoluble protein aggregates. [false2] Ribonucleoprotein granules always contain mRNA. [true1] Ribonucleoprotein granules are dynamic structures that primarily form by liquid-liquid phase separation. [true2]

In 2023 Dr. Ke Zhang published another modifier of (G4C2)30 expression in the fly eye. The modifier was an RNAi targeting basket mRNA. Basket protein promotes stress granule assembly. An image from that paper is shown below.  1) Given the above results, you can conclude that an RNAi targeting basket mRNA is a genetic [suppressor]. 2) Given that basket promotes the formation of stress granules, which is the best conclusion from the above results? [SGs_bad]

RNA foci in Fragile X-associated Tremor/Ataxia Syndrome (FXTAS), Fragile X-associated Primary Ovarian Insufficiency Syndrome (FXPOI), and C9orf72 ALS/FTD might cause/promote disease through a toxic gain-of-function mechanism. How might RNA foci be toxic? (i.e. What might RNA foci do that is bad for a cell?)  (Please answer in four sentences or less and restrict your answer to ideas discussed in lecture.)

Which international comparison is at the center of that article?

How did Dr. Wassarman model Ataxia Telangiectasia (A-T) in his dominant modifier screen?

Select True or False for each statement below. When glutamate binds to metabotropic glutamate receptors (mGluRs): it triggers a conformation change in the receptor that opens an ion channel and depolarizes the neuron. [false1] it triggers an intracellular signaling cascade that results in the translation of mRNAs in dendrites. [true1] Fragile X Messenger Ribonucleoprotein 1 protein (FMRP) is phosphorylated and de-methylated. [false3] it leads to the assembly of neuronal granules that contain FMRP. [false2]