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Which answer best describes the reason for synergistic cancer cell killing by ATR and Wee1 inhibitors? 

You are growing normal(wild-type) organoids, and organoids carrying mutations in Kras-G12D, APC, p53, SMAD4 in different combinations. Your defined organoid media lacks EGF, R-Spondin and Wnt. Which organoids would grow with your media?

The “10x Genomics” platform utilizes a droplet-based microfluidics approach. Which of the following components are critical for assigning transcripts to their specific cell of origin and quantifying distinct RNA molecules? *Multiple answers may be true

Which type of DNA repair causes chromosomal translocations?

Which would promote transition to M-phase in a G2 cell?

Which of the following is NOT a pathway for the repair of double-strand breaks?

Dr. B wants to study tumor suppressive roles of CDKN2A in melanoma. They have generated a germline knockout strain of CDKN2A mice, which develop lymphoma. Based on the etiological information, what modifications should be made to get a melanoma experimental model?

In the Circos plot shown, there is a translocation between Chromosome 11 and which other Chromosome:

What region of the scale below representing levels of ongoing DNA damage is most likely to promote cancer development?

During the preprocessing of scRNA-seq data, “Scaling” is a distinct step from “Normalization.” What is the specific bioinformatic purpose of the Scaling step prior to dimensionality reduction? *Multiple answers may be true