A 29-year-old man with HIV presents with recurrent painful g…

A 29-year-old man with HIV presents with recurrent painful genital ulcers. PCR confirms HSV-2. He reports 8 outbreaks in the past year and a new HSV-seronegative partner. Which is the most effective strategy to reduce both recurrence frequency and transmission? 

A 52-year-old man presents with sudden-onset severe pain, sw…

A 52-year-old man presents with sudden-onset severe pain, swelling, and erythema of the right great toe that began overnight. He describes the pain as “unbearable.” Past medical history includes stage 3 chronic kidney disease (eGFR 45 mL/min) and hypertension, currently treated with lisinopril. Labs show uric acid 9.0 mg/dL, WBC 9,000/µL, and creatinine 1.8 mg/dL. He has no fever or systemic symptoms. Which pharmacologic option is most appropriate for management of his acute flare? 

A 6-week-old male infant presents with fever, irritability,…

A 6-week-old male infant presents with fever, irritability, and poor feeding. Urinalysis is positive for leukocyte esterase and nitrites, and urine culture is pending. The NP considers empiric therapy with trimethoprim–sulfamethoxazole (TMP-SMX). The infant was born at 35 weeks’ gestation and has a history of mild jaundice in the neonatal period. Current labs show total bilirubin 1.2 mg/dL (normal for age), creatinine 0.3 mg/dL, and electrolytes within normal limits. Which concern makes TMP-SMX an inappropriate choice for this patient population?