Phenylketonuria (PKU) is an inherited rare autosomal recessi…

Phenylketonuria (PKU) is an inherited rare autosomal recessive disorder that affects 1/10,000 newborns. PKU is caused by a mutation in the PAH gene that results in a decrease in the metabolism of the amino acid phenylalanine. Assuming H-W conditions apply, what is the frequency of PAH mutant alleles (PKU-causing alleles) in the population?

In Labrador retrievers, black coat color (B) is dominant to…

In Labrador retrievers, black coat color (B) is dominant to brown (b).  Suppose that a black lab is mated with a brown one and the offspring are 4 black puppies and 1 brown puppy.  What can you conclude about the genotype of the black parent with respect to the B gene?

The  human bone disease osteogenesis imperfecta (OI) is usua…

The  human bone disease osteogenesis imperfecta (OI) is usually caused by  a dominant mutation in one of the two genes that produce type 1 collagen, COL1A1 or COL1A2. People with OI have weak bones and joints. Some people can carry the mutation but have no symptoms. Thus, families can unknowingly transmit the mutation from one generation to the next through someone who carries the mutation but does not express the OI phenotype. Which of the following terms best describes this type of non-Mendelian inheritance?