A term neonate with meconium aspiration on CMV shows high pe…

A term neonate with meconium aspiration on CMV shows high peak inspiratory pressures (PIP 28 cm H2O) with poor chest rise and rising PaCO2. Compliance is poor and there is concern for lung injury. Which adjustment best reduces the risk of ventilator-induced lung injury while aiming to improve ventilation?

A 29-week neonate on conventional mechanical ventilation (CM…

A 29-week neonate on conventional mechanical ventilation (CMV) has worsening respiratory acidosis with PaCO2 rising from 50 to 68 mm Hg and pH dropping from 7.31 to 7.22. Current settings: SIMV, rate 30, VT 4 mL/kg, PEEP 5 cm H22O, FiO2 0.35. Which ventilator adjustment is the most appropriate first step?