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Module 5 A postsynaptic neuron normally receives both excita…

Module 5 A postsynaptic neuron normally receives both excitatory input and inhibitory input mediated by GABA. A mutation prevents the GABA receptors from opening their Cl⁻ channels, but excitatory synapses continue to function normally. Using this scenario, analyze how loss of inhibitory signaling affects neural communication. In your response: Predict how the mutation will affect the postsynaptic membrane potential. Explain how the loss of inhibitory input changes the summation of graded potentials. Predict how the mutation will affect the likelihood that the neuron reaches threshold and generates action potentials. Explain why this type of disruption could produce excessive neural activity.

Module 1 A hiker exposed to extreme heat has damage to the h…

Module 1 A hiker exposed to extreme heat has damage to the hypothalamic thermoreceptors that normally detect changes in core body temperature. A second hiker exposed to extreme cold can detect the temperature change normally but is unable to shiver. Analyze how each failure affects temperature regulation. In your response: Identify which part of the homeostatic feedback loop has failed in each hiker: sensor, control center, or effector. Predict how each failure will affect the body’s ability to restore normal temperature. Explain why temperature regulation is still classified as negative feedback even though the response is unsuccessful in these cases.