B Cell Signaling (Moser) Consider the B cell signaling pathw…

Questions

B Cell Signаling (Mоser) Cоnsider the B cell signаling pаthway shоwn below. (A) PLC-gamma activity creates IP3 and DAG. What molecule is the substrate of PLC-gamma? (The substrate molecule is not pictured here). Name one transcription factor induced by PLC-gamma activity. (2 points) (B) Briefly describe two characteristics of an antigen that would allow it to initiate proximal signaling through the BCR and CD21. (2 points) (C) An autoimmune patient has a mutation in the inhibitory receptor Fc-gamma-RIIb. What type of enzyme mediates Fc-gamma-RIIb-mediated termination of signaling? The patient has evidence of increased NF-kappa-B activation in B cells. Ibrutinib is a drug that inhibits Btk. Would ibrutinib be effective at reducing NF-kappa-B activation? Why or why not? (2 points)

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