The current methods used for the detection of pathogenic pri…

The current methods used for the detection of pathogenic prions take advantage of differences in protein folding. For each description given below, identify the method that it applies to. Requires the removal of properly folded prion proteins using protease treatment. [method1] Monitors the conversion of prion misfolding using brain homogenate. [method2] Utilizes an antibody to recognize misfolded prion protein. [method3] Monitors changes in current formed across a synthetic lipid bilayer. [method4] Monitors the accumulation of pathogenic prions using the fluorescent dye Thioflavin T. [method5] Monitors ion movement through alpha-hemolysin generated membrane pores. [method6]