Author: Anonymous

A newborn has recurrent bacterial infections despite normal antibody production. Neutrophils fail to migrate from blood vessels into infected tissues. Which molecule is most likely defective?

A pro-B cell has begun D-JH recombination and expresses Pax5. Which developmental stage is this?

A dendritic cell migrates from infected tissue to a draining lymph node after engulfing bacteria. What is its primary function within the lymph node?

A patient develops bacterial meningitis caused by Neisseria meningitidis. Complement deficiency is suspected. Which complement component is directly responsible for forming pores that lyse bacterial membranes?

A vaccine is designed to generate strong mucosal immunity. Which antibody class is most important at mucosal surfaces?

Fungi and extracellular bacteria stimulate IL-1 and IL-23 in barrier tissues. Which response is induced?

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A fetal tissue sample contains a relatively high proportion of TCRγδ cells compared with adult peripheral blood. Which statement best explains this?

A child has normal B-cell numbers but impaired T-cell development. Thymocytes fail to progress past the DN3 stage. Which event is most likely defective?

A patient’s B cells bind self-antigen with high avidity in the bone marrow. What is the expected outcome if receptor editing fails?