A 52-year-old woman (BMI 34 kg/m²) is 40 minutes into a lapa…

A 52-year-old woman (BMI 34 kg/m²) is 40 minutes into a laparoscopic cholecystectomy under general anaesthesia with sevoflurane and remifentanil. The anaesthesiologist notices the end-tidal CO2 has risen to 74 mmHg despite unchanged ventilator settings. Examination reveals generalised muscle rigidity, jaw clenching, temperature 39.8°C, and heart rate 138 bpm. Arterial blood gas confirms mixed respiratory and metabolic acidosis. What is the most likely diagnosis?

A 28-year-old woman develops a postural headache two days af…

A 28-year-old woman develops a postural headache two days after spinal anaesthesia for caesarean section. The headache worsens when she sits up and improves when she lies flat. Conservative management with hydration and simple analgesics fails after 48 hours. What is the most appropriate next step?