Several members of a family have reported suffering from dys…

Several members of a family have reported suffering from dyspnea, and chest pain or fainting during exercise.  Upon further questioning, many report feeling palpitations as well.  After an extensive family history interview, the pedigree illustrated in the figure was constructed. Which of the following family members is most likely to be a non-penetrant carrier and at risk of similar symptoms?   

The pedigree illustrates a family with acute extrapyramidal…

The pedigree illustrates a family with acute extrapyramidal syndrome associated with mild OTC deficiency. Which of the following individuals are most likely to be obligate carriers (or heterozygotes) of the OTC pathogenic variant?    *Age at death is given for individuals III-3, III-4, III-12 and IV-6, and death in infancy (inf) is annotated for individuals II-3, III-15, III-16, IV-5.