The first three steps of the β oxidation of an unsaturated f…

The first three steps of the β oxidation of an unsaturated fatty acid are comparable to reactions occurring in the citric acid cycle (CAC). If the three steps involve oxidation, followed by hydration, followed by a second oxidation, which of the following CAC enzymes catalyze these similar reactions?

Patients with pyruvate dehydrogenase deficiency show high le…

Patients with pyruvate dehydrogenase deficiency show high levels of lactic acid in the blood. However, in some cases, treatment with dichloroacetate (DCA) lowers lactic acid levels. DCA targets the activity of pyruvate dehydrogenase kinase (PDK). Identify how DCA acts to stimulate pyruvate dehydrogenase activity.