Author: Anonymous

You have conducted a rodent study to assess the toxicity of…

You have conducted a rodent study to assess the toxicity of compound X.  For the study, 2 sets of rats were exposed to compound X; Group 1 was adult males (1 year old) and Group 2 was male rat pups (1 week old). The exposure was through a dietary route. Compound X was mixed into the food at 3 different doses and the experiment lasted 1 week. The endpoint measured was lethality. Here are the study results: Dose Adult (lethality) Pup (lethality) Control (none) 0% 0% 1 mg/kg 0% 20% 10 mg/kg 0% 50% 25 mg/kg 10% 100% 50 mg/kg 20% 100% 100 mg/kg 50% 100%   Based on the LD50s for adults and pups, what can you infer from this data (assuming all aspects of the experiment were performed the same way)?

You have conducted a rodent study to assess the toxicity of…

You have conducted a rodent study to assess the toxicity of compound X.  For the study, 2 sets of rats were exposed to compound X; Group 1 was adult males (1 year old) and Group 2 was male rat pups (1 week old). The exposure was through a dietary route. Compound X was mixed into the food at 3 different doses and the experiment lasted 1 week. The endpoint measured was lethality. Here are the study results: Dose Adult (lethality) Pup (lethality) Control (none) 0% 0% 1 mg/kg 0% 20% 10 mg/kg 0% 50% 25 mg/kg 10% 100% 50 mg/kg 20% 100% 100 mg/kg 50% 100%   These data (for either adults or pups) represent a non-monotonic dose response relationship.