Dr. Wassarman conducted a GWAS in Drosophila to identify gen…

Dr. Wassarman conducted a GWAS in Drosophila to identify genetic variants that influence early mortality after traumatic brain injury. He included 179 inbred lines in his GWAS (i.e., the DGRP lines). In the figure below, which of the fly lines indicated by the three arrows contains a genome with either the greatest number of protective genetic variants and/or protective genetic variants with the biggest effect size?

During the development of (post-mitotic) neurons in the eye,…

During the development of (post-mitotic) neurons in the eye, cells in the larval eye-disc first undergo rounds of mitosis and then fully differentiate into neurons. As illustrated in the image below, Dr. Wassarman started with Drosophila larvae that were heterozygous for an ATMmutation and a GFP gene. He then used the FLP/FRT system (which is active during the mitosis that proceeds neuronal differentiation) to make homozygous clones of differentiated neurons.   Cells inside the red square in the image above are post-mitotic differentiated neurons. Would any cells inside the red square in the image above stain for the mitotic marker H3-pS10? If so, which ones?

Dr. Wassarman discovered a genetic suppressor of A-T in his…

Dr. Wassarman discovered a genetic suppressor of A-T in his fly model of the disease.   What is the genotype of the suppressor? Choose the letter that corresponds to the correct genotype below.  A. stringmutant / stringwild-type (non-mutant) B. stringmutant / stringmutant C. stringwild-type (non-mutant) / stringwild-type (non-mutant) D. P35mutant / P35wild-type (non-mutant) E. P35mutant / P35mutant   Be careful when you mark your selection because the order of the letters might be mixed-up.