A 52-year-old woman with a 25–pack-year history of smoking presents to discuss pharmacologic options for cessation. She reports prior unsuccessful attempts with nicotine replacement therapy. Her past medical history includes type 2 diabetes mellitus and obesity, but no history of seizures, head trauma, or eating disorders. She is not currently depressed but reports mild anhedonia when she has tried to quit in the past. The NP considers starting bupropion SR. Through which primary mechanism does this medication reduce nicotine cravings and withdrawal symptoms?
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