A 34-year-old female presents for a physical exam. She is ne…

A 34-year-old female presents for a physical exam. She is new to the practice and enrolled because she and her family had recently moved to the area and her last physical was more than 1 year ago. On review of her history, the patient has had 2 normal vaginal deliveries and is currently on no oral contraceptive medication, as her husband has had a vasectomy. She has had no chronic medical problems. Her only medications are a multivitamin and Vitamin E. On review of her records, you note that she had a relatively normal fasting lipid profile performed 5 years ago, is up to date on her Tetanus shot, and has had normal Pap smears over the past 5 years. The records also seem to indicate that she has gained about 10 lbs in weight over the past year. Her physical exam is within normal; she is about 20% overweight. You ask the patient to do a repeat fasting lipid profile and the values are as follows: Total cholesterol is 342 mg/dL (normal under 200) LDL Cholesterol 225 mg/dL (normal 60-160) HDL Cholesterol 75 mg/dL (normal 30-80) Triglyceride level 210 mg/dL (normal under 150) What would be the most appropriate next step in the diagnostic evaluation of this patient?

A 24-year-old man is referred to an endocrinologist for paro…

A 24-year-old man is referred to an endocrinologist for paroxysms of headaches associated with elevated blood pressure and palpitations. He is otherwise healthy, although he notes a family history of thyroid cancer. His physical examination is significant for the findings shown in Figures A, B, and C (see images). His thyroid is normal in size, but there is a 2.5 cm nodule palpable in the right lobe. On further workup, it is found that he has elevated plasma-free metanephrines and a normal TSH. Fine-needle aspiration of the thyroid nodule stains positive for calcitonin. The endocrinologist suspects a genetic syndrome. What is the most likely inheritance pattern?

A 55-year-old female with a 15-year history of Type II diabe…

A 55-year-old female with a 15-year history of Type II diabetes comes to your office for follow up of her diabetes. Her spot albumin/creatinine ratio was 100 mg/g 4 months ago and was confirmed at 100 mg/g yesterday, consistent with stable microalbuminuria. Her urinary analysis shows no cells, casts, or blood. Her creatinine is 0.7mg/dl and her estimated glomerular filtration rate is 95 ml/min (normal range). Which of the following medications should you prescribe to help prevent her progression from micro to macroalbuminuria and to help prevent progressive decline in glomerular filtration rate?

A 30-year-old man presents to your clinic complaining of exc…

A 30-year-old man presents to your clinic complaining of excessive thirst and frequent urination for the past few months. Urine testing reveals a low urine osmolarity, which fails to increase after subjecting the patient to a water deprivation test and injection of desmopressin. Further into the encounter, the patient reveals that he has been on a mood stabilizer for bipolar disorder for several years. Which of the following is the most likely cause of his polyuria?

A 48-year-old female presents to the clinic due to 3 weeks o…

A 48-year-old female presents to the clinic due to 3 weeks of increased thirst and increased urination. She has a history of obesity, hypertension and depression and has smoked a pack of cigarettes daily for the past 28 years. Her current medications include lisinopril and sertraline. T 98.5°F, BP 148/90 mmHg, HR 84/min, and RR 15/min. Her physical exam is normal, and her laboratory values are as follows:   Serum: Na+: 140 mEq/L K+: 4.4 mEq/L HCO3-: 21 mEq/L BUN: 38 mg/dL Creatinine: 1.1 mg/dL Glucose: 215 mg/dL Which of the following is the most appropriate screening test for nephropathy in this patient?

 A 22-year-old female presents with urinary frequency. Her B…

 A 22-year-old female presents with urinary frequency. Her BMI is 41. A urinalysis is positive for glucose. Her random blood sugar is 257 mg/dL, hemoglobin A1c is 8.5%, and C-peptide is 1.5 ng/mL. She is diagnosed with type 2 diabetes; diet and exercise are recommended. What is the drug of choice for managing her diabetes?

A 65-year-old male is noted by his family to have developed…

A 65-year-old male is noted by his family to have developed a short shuffling gait and difficulty getting up from a seated position.  On physical examination, you note a resting tremor and rigidity of the joints with passive range of motion.  Based on these findings, which of the following conditions is the most likely diagnosis for this patient?