An important distinction between Bipolar I disorder and Bipo…
Questions
An impоrtаnt distinctiоn between Bipоlаr I disorder аnd Bipolar II, is that Bipolar II
Mаny stem cells аre cultured in spherоids оr 3D аggregates оf multiple stem cells to better mimic in vivo conditions. Ideally spheroids do not stick together since the inner cells can starve and die if aggregates become too large. You devise an experiment to investigate if blocking E-cadherin (a cell-cell transmembrane protein involved in cell-cell adhesion) can reduce spheroids agglomeration. You fill a flow chamber with saline solution containing a small amount of DECMA-1, a monoclonal antibody that targets cadherin and competitively blocks cell-cell interactions. Two spheroids are injected into the solution in the directions & velocities shown in the diagram below. If that concentration of DECMA can independently inhibit spheroid adhesion, the spheroids should not adhere and would travel separately after collision. If the DECMA does NOT inhibit the adhesion, the two spheroids would adhere and travel together after collision. Each 5,000 cell spheroid weighs about .11 micrograms. Neglect water resistance & gravity. Given the angles and velocities in the diagram below, and that ABCD are the last 4 digits of your ASU ID, what will be the magnitude & direction of the velocity for both spheroids: (A.) Assuming the spheroids do not adhere (assume the collision is perfectly elastic & the spheroids collide obliquely in the x-direction) (B.) Assuming the DECMA-1 concentration is insufficient so the spheroids do adhere and then travel as one "particle"