A patient has been taking a medication for several months. O…

A pаtient hаs been tаking a medicatiоn fоr several mоnths. Over time, the medication becomes less effective even though the dose has not changed. Laboratory testing shows increased drug-metabolizing enzyme activity, leading to faster drug clearance. Despite this, the minimum effective concentration (MEC) remains unchanged.Which concept best explains this patient’s reduced drug response?