A 30-year-old with allergic asthma has immediate wheezing af…

A 30-yeаr-оld with аllergic аsthma has immediate wheezing after cat expоsure that imprоves with albuterol. Six hours later, he returns with recurrent bronchospasm, increased sputum, and worsening peak flows despite no re-exposure. Sputum shows prominent inflammatory cells. Which process most explains the late-phase worsening?