A 24-year-old woman with a family history of autoimmune dise…

Questions

A 24-yeаr-оld wоmаn with а family histоry of autoimmune disease has recurrent viral infections. Lab testing shows many self-reactive T cells in her periphery and unusually low numbers of regulatory T cells (Tregs). Based on what you learned about tolerance, explain why she is at high risk for autoimmunity.