For each of the following sentences, fill in the blanks with…

Fоr eаch оf the fоllowing sentences, fill in the blаnks with the best word or phrаse selected from the list.  Cells can signal to each other in various ways.  The [1] methods of cell signaling do not require the release of a secreted molecule and are used for very localized signaling events. During [2] signaling, the signal released remains in the neighborhood of the secreting cell and thus acts as a local mediator on nearby cells.  An example of a signal molecule that acts locally is [3].  Insulin is delivered via [4] signaling. Signaling that involves new protein synthesis is [5] than signaling that requires the modification of existing proteins.