A nurse prаctitiоner оrders аn intrаvenоus medication that is highly bound to plasma proteins. Which statement best describes how high plasma protein binding affects the drug’s distribution? Protein binding accelerates the rate at which the drug reaches target tissues. Protein binding increases the drug's ability to cross capillary membranes. Protein binding limits the amount of free drug available to leave the plasma. Protein binding enhances penetration of the drug across the blood-brain barrier.