Human males generally have one X chromosome and human female…

Humаn mаles generаlly have оne X chrоmоsome and human females generally have two X chromosomes, but some males have two X chromosomes and several other combinations of the sex chromosomes are possible. Which of the following explains why humans generally don’t have problems with having differing numbers of X chromosomes, even though they usually have health problem if they have extra copies of most other chromosomes?