Optional up to 2 points of extra credit: SARS-CoV-2, the vir…
Questions
Optiоnаl up tо 2 pоints of extrа credit: SARS-CoV-2, the virus thаt causes COVID, results in long COVID in a percentage of individuals. Estimates of this number vary for a number of reasons, but many studies have suggested 10-20% of those infected go on to develop long term symptoms characteristic of long COVID. One of these symptoms is fatigue (exhaustion). Although research is ongoing, the virus is thought to impact mitochondria in a number of ways. One such way is via the suppression of oxidative phosphorylation and the promotion of glycolysis within the cell. 1. What would be the impact on ATP production of the cell of a shift away from oxidative phosphorylation and toward increased glycolysis? How would increased glycolysis impact the production of precursor metabolites (carbon intermediates), and how might this benefit the virus? 2. How might this lead to fatigue (exhaustion) in the individual? Please be specific and explain clearly.