A 32-yeаr-оld previоusly heаlthy mаle sоftware engineer presents urgently to his primary care physician reporting extreme, unquenchable thirst and massive urine output for the past 5 days. He describes drinking 10-15 liters of water per day. Urinating large volumes (estimated 8-12 liters/day) of clear, watery urine, waking him up 5-6 times nightly for restroom. Constant feeling of dry mouth feeling fatigued and slightly lightheaded. No recent illness, head trauma, or surgery. BP 125/80 mmHg (lying), 115/75 mmHg (standing). Pulse 88 bpm Urine appears clear with low specific gravity. Urine osmolarity is 75 mOsm/kg Serum Sodium Na+158 mmol/L, Serum Osmolality: 310 mOsm/kg) ,. Plasma Glucose: normal ADH challenge test shows dramatically decrease in urine output within 1-2 hours. Urine Osmolality rises sharply from 75 mOsm/kg to 650 mOsm/kg. Serum osmolarity and Na+ start to trend down. What is the most appropriate medical treatment of his condition?
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