Suppose a team of researchers investigated the effect of dri…

Questions

Suppоse а teаm оf reseаrchers investigated the effect оf drinking caffeinated beverages (i.e., yes versus no) on migraines among American women aged 18-40. The researchers hypothesized that pregnancy might be a confounder of this effect, as women who are pregnant are less likely to drink caffeinated beverages, and pregnancy increases the risk of migraines. To minimize confounding by pregnancy, the researchers performed stratified analyses. The results from these stratified analyses are reported in Table 1. Table 1. Stratified effect estimates from the hypothetical study on caffeine intake and migraines. Estimates for the subsample of pregnant women Estimates for the subsample women who are not pregnant Risk difference 0.05 0.05 Risk ratio 1.50 2.00 The researchers would like to recombine the stratified effect estimates reported in Table 1 using Mantel-Haenszel methods. Is it appropriate to apply the Mantel-Haenszel method to recombine the stratum-specific estimates of the risk differences (yes/no)? (1 point) Describe why it is/is not appropriate to apply the Mantel-Haenszel method (max. 2 points). Is it appropriate to apply the Mantel-Haenszel method to recombine the stratum-specific estimates of the risk ratios (yes/no)? (1 point) Describe why it is/is not appropriate to apply the Mantel-Haenszel method (max. 2 points).