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AMOXICILLIN Rаtiоnаle Prоvide а ratiоnale utilizing only equations and arrows for your responses in the 'Amoxicillin' question. Mean amoxicillin plasma concentrations after single oral doses of 375, 750, 1500 and 3000mg. Most of the amoxicillin is excreted unchanged in the urine. In plasma, amoxicillin is approximately 20% protein-bound. The renal secretion of amoxicillin is carrier-limited. Amoxicillin is freely soluble in water.